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Constipation appearing in week 2 to 4: Common (affects 25% to 30% of patients) Caused by slowed colonic transit, not dehydration alone Responds to fiber supplementation (25 to 30 g per day), magnesium citrate (400 mg daily), or polyethylene glycol (MiraLAX) If severe or accompanied by abdominal pain, rule out bowel obstruction (rare but reported in post-marketing surveillance) Hair thinning appearing at 3 to 6 months: Caused by rapid weight loss (more than 1% to 2% body weight per week) and telogen effluvium Not a direct drug effect

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